Endocrine Abstracts

The global prevalence of obesity continues to rise, creating a growing need for new effective medicines. Selective targeting of visceral obesity (fat around the internal organs) would be particularly advantageous because it carries a greater risk for cardiometabolic diseases. The ectonucleotide pyrophosphatase (ENPP) enzyme family participates in several pathological conditions including diabetes (ENPP1, and ENPP2, also known as autotaxin) and vascular dysfunction (ENPP3-4). O...

Background: Macrosomia (BW >4.5 kg) is a well-recognised complication of maternal hyperglycaemia and is associated with poor maternal and foetal outcomes. Traditional risk factors of macrosomia do not fully explain all variation as it can happen in normoglycaemia and in well-controlled diabetes. The relative contributions of these factors in different ethnicities are unknown. We investigated the predictors of BW in South Asian (SA) and White Caucasian (WC) pregnancies, and...